"We use cold plasma therapy and the CPT®patch to supplement traditional wound care for our difficult and poorly healing wounds."

Prof. Dr. med. Ole Goertz
Chief Physician for Plastic, Reconstructive & Aesthetic Surgery,
Martin Luther Hospital, Berlin
CPT® Plasma.Competence.Center.

for your treatment success

"We use cold plasma therapy and the CPT®patch to supplement traditional wound care for our difficult and poorly healing wounds."

Prof. Dr. med. Ole Goertz
Chief Physician for Plastic, Reconstructive & Aesthetic Surgery,
Martin Luther Hospital, Berlin
CPT® Plasma.Kompetenz.Zentrum.

Treatment with the CPT®patch

The application of the dressing is simple and safe

For treatment, apply a CPT®patch to the wound area and operate it by means of the CPT®cube.

For treatment, apply a CPT®patch to the wound area and operate it by means of the CPT®cube.

1. open sterile packaging

2. remove CPT®patch

3. remove protective foil

3. apply CPT®patch

The treatment starts automatically after pressing the start/stop key on the CPT®cube. The treatment lasts 2 minutes.

The treatment can be repeated as often as necessary until the desired therapeutic success has been achieved. However, it should be noted that there should be at least 24 hours between each plasma treatment.

The treatment can and should be applied adjuvantly to other forms of therapy or recommendations of the corresponding guidelines at the discretion of the treating physician. Following plasma treatment, the wound is covered with commercially available wound dressings.

The active components explained

Active components (excerpt from position paper on risk potential and application perspectives of cold atmospheric pressure plasma in medicine, NZPM)

According to the current international state of research, the main active components of cold atmospheric pressure plasmas are reactive nitrogen and oxygen species (RNS, ROS), UV radiation and electric fields.

According to the current international state of research, the main active components of cold atmospheric pressure plasmas are reactive nitrogen and oxygen species (RNS, ROS), UV radiation and electric fields.

Reactive nitrogen and oxygen species (RNS, ROS) are formed locally and briefly by coupling electrical energy into gases that are not biologically active per se (argon, helium, nitrogen, oxygen, air and mixtures thereof) and subsequent interaction with adjacent media (atmospheric air, liquids, surfaces). In principle, the same reactive species are sometimes produced in the human body as part of normal metabolism and in some cases have important functions in controlling and mediating physiological and pathological processes. Briefly elevated doses of these RNS and ROS can be effectively detoxified by the body's own systems.

UV radiation is used medically in phototherapy and photochemotherapy, among other things. In this context, as well as under the aspect of general personal and occupational safety, also outside the medical environment, limit values have been defined for UV exposure, which are significantly undercut in connection with the use of cold atmospheric pressure plasma. 

Two important findings of basic plasma medicine research in recent years are:

1. biological plasma effects on cells and in tissues are mediated via changes in the fluid cell environment.

2. for biological effects induced by plasma action, oxidizing species, so-called reactive oxygen and nitrogen species (ROS, RNS), introduced into the liquid or formed in the liquid play a dominant role.

The same reactive species (ROS, RNS) are also produced in the human body as part of normal metabolism and in some cases have important functions in controlling and mediating physiological and pathological processes. The most important ROS and RNS are hydroxyl radical (OH-), hydrogen peroxide (H2O2), superoxide or hyperoxide (O2--), nitric oxide (NO-), nitrogen dioxide (NO2-) and peroxynitrite (ONOO-). They play an important role in wound healing processes, for example. This finding provides an essential scientific basis for the concept of plasma-assisted wound healing, in which, in addition to the well-known antibacterial/disinfectant plasma effect, stimulation of tissue regeneration is also to be achieved by plasma action. One mechanism of plasma action is thus based on the support of endogenous functions which - for example in the case of non-healing chronic wounds - cannot be sufficiently effective due to disease-related disorders. Furthermore, it is known that a certain basic concentration of RNS and ROS is always present in human cells. Due to the physiological occurrence of these species, short-term elevated concentrations can be effectively detoxified by endogenous systems [16-24]. Transcriptome analyses of in vitro plasma-treated human cells have shown that genes associated with the cellular stress response are increasingly upregulated and antioxidant active enzymes are produced as a result of plasma treatment [25]. 

Since plasma treatments are local and time-limited, under normal conditions the risk of side effects associated with entry of these ROS and RNS into the tissue is expected to be exceptionally low. 

3. ultraviolet radiation (UV radiation)

UV-B radiation in particular is used in dermatology as part of phototherapy. According to the recommendations of the German Dermatological Society (DDG) on phototherapy and photochemotherapy, initial doses of between 20 and 60 mJ/cm2 are recommended for broad-spectrum UV-B application (280-320 nm) depending on the skin type, and doses of between 200 and 600 mJ/cm/WTA are recommended for narrow-spectrum UV-B treatment (311 nm).

A comparison with solar radiation shows that the UV intensity emitted by the cold atmospheric pressure plasma sources used in clinical testing or approved as medical devices to date is far below that of sunlight.

For the plasma sources currently certified as medical devices, it has been shown that under the recommended conditions of use (working distance, treatment time), the maximum permissible daily UV dose is significantly undercut.

4. electric fields

Electric fields can first be divided into direct and alternating fields. Furthermore, the pulsation of such signals as well as a mono- or bi-phase modulation allows a high parametric diversity. Technical frequencies are in the range of a few Hz up to the GHz range. Devices that work exclusively with electric fields have been established for many years for use in and on the human body and can induce an electric current flow in biological tissue as a result of the electric fields. Regardless of the device, the use of electrical signals for electrostimulation offers a variety of proven applications in medical care. For example, cell movement of immune cells (macrophages and granulocytes) and migration of skin cells (keratinocytes) and corneal epithelium can be specifically influenced in response to an electric field, proliferation behavior of connective tissue cells (fibroblasts) is stimulated, and for new vessel formation (angiogenesis) and nerve growth, the electric field is also important. Finally, in vivo studies using electric fields have shown an antibacterial effect on both gram-negative and gram-positive bacteria.

In recent years, research in the field of bioelectricity has demonstrated significant links between endogenous electric fields and the wound healing process. A meta-analysis by Gardner et al. was performed using data sets from 15 clinical trials with the goal of quantifying the effect of electrical stimulation (ES) on chronic wound healing. Treatments with ES achieved an average wound reduction of 22.2% per week, compared with only 9.1% in control groups. In the published sub-results of Cochrane Review #077, healing success (wound closure) using electrical stimulation was compared to placebo control. This question was investigated in 13 of the 20 studies. The analysis showed that twice as many (OR=2.12; 95% CI: 1.55 - 2.90) wounds were healed by treatment with electrostimulation (verum) compared to controls.


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Side effects

Side effects/tolerance of cold plasma

At the current state of clinical research, no clinically relevant side effects are known.

At the current state of clinical research, no clinically relevant side effects are known.

Study situation on cold plasma

An extensive body of studies shows the effectiveness

The antimicrobial efficacy was confirmed by further studies. Chronic wounds of 34 patients were treated with cold plasma or in combination with a wound antiseptic. The combination therapy showed the best efficacy [1].

In a monocenter, randomized-controlled clinical trial, seven patients each with at least 12-week-old chronic ulcers underwent plasma treatment or no treatment in addition to normal wound care. The plasma source was a dielectric-restrained discharge powered by air. Wound healing occurred similarly to standard therapy, while wound areas colonized with bacteria decreased by a mean of 88% in wounds treated with Palsma [2].

In another study with five subjects, two artificial wounds were created on each arm using negative pressure and the healing process was observed. The four wounds received either no treatment (A) a treatment with cold plasma (B), Octenisept© (C) or a plasma treatment followed by a treatment with Octenisept© (D). Normalized to initial area, plasma-treated wounds (B) healed fastest at all measured time points, while untreated wounds (A) healed slowest [3].

Sixteen patients included in the study (ten women and six men) with chronic leg ulcers were each treated with cold plasma three times a week over a period of two weeks. In addition to measuring antimicrobial activity, the aim of the study was to investigate the effect on wound healing. 

The parameters compared were, in addition to the number of bacterial colonies per square centimeter, the size of the wound surface and the change in wound volume. The authors concluded that the immediate antimicrobial effect of the two treatment methods was largely comparable. Plasma therapy was very well tolerated by patients and, according to the authors, is unlikely to cause allergies due to its physical principle of action [4].

In a more extensive study with 70 patients, a tendency towards improved healing was determined on chronic ulcers treated with cold plasma - compared to untreated wounds [5]. In addition, another randomized-controlled trial with 40 patients showed significantly improved healing after plasma treatment of acute wounds after skin grafts [6]. A summary of the current status of plasma application in animal experiments, in vivo, and clinical studies and case reports is also the subject of a recent review [7].

A risk assessment with reference to plasma species (temperature, UV radiation and free radicals) did not reveal any increased risks for humans [8].

Based on the state of clinical research, plasma applications in dermatology as well as plastic and aesthetic surgery currently have the highest prospects of success. The use of antimicrobial plasma effects, plasma-assisted stimulation of tissue regeneration and inflammation-modulating plasma effects are the focus of therapeutic indications.


[1] M. Klebes, C. Ulrich, F. Kluschke, A. Patzelt, S. Vandersee, H. Richter, A. Bob, J. Hutten, J.T. Krediet, A. Kramer, Combined antibacterial effects of tissue-tolerable plasma and a modern conventional liquid antiseptic on chronic wound treatment, Journal of biophotonics, 8 (2015) 382-391.

[2] F. Brehmer, H. Haenssle, G. Daeschlein, R. Ahmed, S. Pfeiffer, A. Görlitz, D. Simon, M. Schön, D. Wandke, S. Emmert, Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm® VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622), Journal of the European Academy of Dermatology and Venereology, 29 (2015) 148-155.

[3] S. Vandersee, H. Richter, J. Lademann, M. Beyer, A. Kramer, F. Knorr, B. Lange-Asschenfeldt, Laser scanning microscopy as a means to assess the augmentation of tissue repair by exposure of wounds to tissue tolerable plasma, Laser Physics Letters, 11 (2014) 115701.

[4] C. Ulrich, F. Kluschke, A. Patzelt, S. Vandersee, V. Czaika, H. Richter, A. Bob, J. von Hutten, C. Painsi, R. Hügel, Clinical use of cold atmospheric pressure argon plasma in chronic leg ulcers: A pilot study, Journal of wound care, 24 (2015).

[5] G. Isbary, W. Stolz, T. Shimizu, R. Monetti, W. Bunk, H.U. Schmidt, G.E. Morfill, T.G. Klämpfl, B. Steffes, H.M. Thomas, J. Heinlin, S. Karrer, M. Landthaler, J.L. Zimmermann, Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: results of an open retrospective randomized controlled study in vivo, Clinical Plasma Medicine, 1 (2013) 25-30.

[6] J. Heinlin, J.L. Zimmermann, F. Zeman, W. Bunk, G. Isbary, M. Landthaler, T. Maisch, R. Monetti, G. Morfill, T. Shimizu, J. Steinbauer, W. Stolz, S. Karrer, Randomized placebo-controlled human pilot study of cold atmospheric argon plasma on skin graft donor sites, Wound Repair Regen, 21 (2013) 800-807.

[7] T. Von Woedtke, H.R. Metelmann, K.D. Weltmann, Clinical plasma medicine: state and perspectives of in vivo application of cold atmospheric plasma, Contributions to Plasma Physics, 54 (2014) 104-117.

[8] J. Lademann, H. Richter, A. Alborova, D. Humme, A. Patzelt, A. Kramer, K.-D. Weltmann, B. Hartmann, C. Ottomann, J.W. Fluhr, Risk assessment of the application of a plasma jet in dermatology, Journal of biomedical optics, 14 (2009) 054025-054025-054026.

Our goal: the healing of chronic wounds.

Our solution: therapy with cold plasma.


If you have any questions regarding reimbursement, please contact us.

You can find information on data protection here

If you have any questions regarding reimbursement, please contact us.
You can find information on data protection here